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2),(max-width: 599px) and (min-resolution: 2dppx),(max-width: 599px) and (min-resolution: 192dpi)\" srcSet=\"https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-mobileMasterAt3x-v2.jpg?quality=75&amp;auto=webp&amp;disable=upscale&amp;width=1200\"\/><source media=\"(max-width: 599px) and (min-device-pixel-ratio: 1),(max-width: 599px) and (min-resolution: 1dppx),(max-width: 599px) and (min-resolution: 96dpi)\" srcSet=\"https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-mobileMasterAt3x-v2.jpg?quality=75&amp;auto=webp&amp;disable=upscale&amp;width=600\"\/><img alt=\"An illustration of multiple, numbered birthday candles melting at different speeds. \" class=\"css-rq4mmj\" src=\"https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-articleLarge.jpg?quality=75&amp;auto=webp&amp;disable=upscale\" srcSet=\"https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-articleLarge.jpg?quality=75&amp;auto=webp 600w,https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-jumbo.jpg?quality=75&amp;auto=webp 1024w,https:\/\/static01.nyt.com\/images\/2025\/03\/06\/well\/06WELL-NON-LINEAR-AGING\/06WELL-NON-LINEAR-AGING-superJumbo.jpg?quality=75&amp;auto=webp 2048w\" sizes=\"((min-width: 600px) and (max-width: 1004px)) 84vw, (min-width: 1005px) 60vw, 100vw\" decoding=\"async\" width=\"600\" height=\"400\"\/><\/picture><\/div><figcaption data-testid=\"photoviewer-children-ImageCaption\" class=\"css-ktho12 e3rygrp0\"><span class=\"css-14fe1uy e1z0qqy90\"><span class=\"css-1ly73wi e1tej78p0\">Credit...<\/span><span><span aria-hidden=\"false\">Alberto Miranda<\/span><\/span><\/span><\/figcaption><\/figure><\/div><div class=\"css-p6m5rf\"><div class=\"byline-container css-1e2jphy epjyd6m2\"><div class=\"css-233int epjyd6m1\"><p class=\"css-4anu6l e1jsehar1\"><span class=\"byline-prefix\">By <\/span><span class=\"css-1baulvz last-byline\" itemProp=\"name\">Mohana Ravindranath<\/span><\/p><div class=\"css-1gqes1i epjyd6m0\"><\/div><\/div><\/div><\/div><div class=\"css-1c72mta\"><time class=\"css-kx0gap e16638kd0\" dateTime=\"2025-03-06T05:00:03-05:00\">March 6, 2025, <span class=\"css-epvm6\">5:00 a.m. ET<\/span><\/time><\/div><\/header><div id=\"NYT_ABOVE_MAIN_CONTENT_REGION\" data-testid=\"region\"><\/div><section name=\"articleBody\" class=\"meteredContent css-1r7ky0e\"><div class=\"css-s99gbd StoryBodyCompanionColumn\" data-testid=\"companionColumn-0\"><div class=\"css-53u6y8\"><p class=\"css-at9mc1 evys1bk0\">For many people, aging feels like it happens in stops and starts. After a period of smooth sailing, one day, seemingly out of the blue, you have achy knees.<\/p><p class=\"css-at9mc1 evys1bk0\">\u201cYou wake up in the morning and you suddenly feel old,\u201d said Dr. Steve Hoffmann, a computational biology professor at the Leibniz Institute on Aging in Jena, Germany. \u201cThat\u2019s sort of the takeaway.\u201d<\/p><p class=\"css-at9mc1 evys1bk0\">It turns out there may be a scientific basis for this experience. By analyzing <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2023\/12\/19\/well\/live\/biological-age-testing.html\" title=\"\">age-related markers<\/a>, such as proteins and DNA tags in the bloodstream, some scientists are coming to understand that aging in adulthood is not a linear process, but perhaps one that jumps dramatically at certain points in one\u2019s life.<\/p><p class=\"css-at9mc1 evys1bk0\">Here\u2019s what they\u2019ve learned so far, and what it could ultimately mean for your health and life span.<\/p><\/div><aside class=\"css-ew4tgv\" aria-label=\"companion column\"><\/aside><\/div><div data-testid=\"Dropzone-1\"><\/div><div class=\"css-s99gbd StoryBodyCompanionColumn\" data-testid=\"companionColumn-1\"><div class=\"css-53u6y8\"><h2 class=\"css-1u37br4 eoo0vm40\" id=\"link-e0f5dac\">What does \u2018nonlinear aging\u2019 look like?<\/h2><p class=\"css-at9mc1 evys1bk0\">Scientists have long suspected that aging may happen in bursts, but they only began using molecular signals to measure the pace of aging in the past decade or so.<\/p><p class=\"css-at9mc1 evys1bk0\">A <a class=\"css-yywogo\" href=\"https:\/\/www.nature.com\/articles\/s43587-024-00692-2\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">widely covered Stanford study<\/a> published last year tracked several molecular changes associated with aging in blood samples gathered from 108 adults between age 25 and 75. By comparing samples from different subjects of different ages, it found that people seemed to age more rapidly around age 44, and again around 60. The clusters of changes in the first spike appeared to be mostly related to fat and alcohol metabolism, as well as muscle function, and the second spike mostly to immune dysfunction and muscle function. 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technologies are giving scientists a better understanding of how the process actually works.\"}],\"textAlign\":\"LEFT\"},\"timestampBlock\":{\"__typename\":\"TimestampBlock\",\"align\":\"LEFT\",\"showUpdatedTimestamp\":null,\"timestamp\":\"2025-03-06T10:00:03.000Z\"}},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"For many people, aging feels like it happens in stops and starts. After a period of smooth sailing, one day, seemingly out of the blue, you have achy knees.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":0},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"\u201cYou wake up in the morning and you suddenly feel old,\u201d said Dr. Steve Hoffmann, a computational biology professor at the Leibniz Institute on Aging in Jena, Germany. \u201cThat\u2019s sort of the takeaway.\u201d\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":1},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"It turns out there may be a scientific basis for this experience. By analyzing \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2023\\u002F12\\u002F19\\u002Fwell\\u002Flive\\u002Fbiological-age-testing.html\"}],\"text\":\"age-related markers\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\", such as proteins and DNA tags in the bloodstream, some scientists are coming to understand that aging in adulthood is not a linear process, but perhaps one that jumps dramatically at certain points in one\u2019s life.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":true,\"bad\":false,\"index\":2},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Here\u2019s what they\u2019ve learned so far, and what it could ultimately mean for your health and life span.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":true,\"adsDesktopHoldout\":true,\"adsHybrid\":true,\"adsMobile\":true,\"adsMobileHoldout\":false,\"bad\":false,\"index\":3},{\"__typename\":\"Heading2Block\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"What does \u2018nonlinear aging\u2019 look like?\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Scientists have long suspected that aging may happen in bursts, but they only began using molecular signals to measure the pace of aging in the past decade or so.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":4},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"A \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.nature.com\\u002Farticles\\u002Fs43587-024-00692-2\"}],\"text\":\"widely covered Stanford study\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" published last year tracked several molecular changes associated with aging in blood samples gathered from 108 adults between age 25 and 75. By comparing samples from different subjects of different ages, it found that people seemed to age more rapidly around age 44, and again around 60. The clusters of changes in the first spike appeared to be mostly related to fat and alcohol metabolism, as well as muscle function, and the second spike mostly to immune dysfunction and muscle function. The first spike could help explain why people seem to have more trouble \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2025\\u002F01\\u002F09\\u002Fwell\\u002Falcohol-middle-age.html\"}],\"text\":\"processing alcohol\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" starting in their 40s, and why they become more prone to illness in their 60s, said Michael Snyder, a professor of genetics at Stanford Medicine and study coauthor.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":5},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Also last year, a \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F38594255\\u002F\"}],\"text\":\"study on mice\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" coauthored by Dr. Hoffmann found that sudden chemical modifications to DNA occurred in the rodents\u2019 early-to-mid life and again in mid-to-late life, suggesting there were three discrete stages of aging.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":true,\"bad\":false,\"index\":6},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"And in a \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F31806903\\u002F\"}],\"text\":\"2019 study\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" looking at the blood plasma of over 4,000 people, scientists reported there were significant jumps in concentrations of proteins associated with aging in the fourth, seventh and eighth decades of life.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":true,\"adsMobile\":true,\"adsMobileHoldout\":false,\"bad\":false,\"index\":7},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Other experts think aging doesn\u2019t necessarily happen in short spurts, but rather in longer phases. Steve Horvath, who is widely considered to have pioneered the biological aging tools known as epigenetic clocks, said a \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F24138928\\u002F\"}],\"text\":\"2013 study\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" he conducted found that the rate of aging follows a steep curve from early childhood until puberty, but becomes linear after age 20. (Dr. Horvath is now principle investigator at Altos Labs, a biotechnology company focused on improving cell health and slowing aging-related disease.)\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":true,\"adsDesktopHoldout\":true,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":8},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"There\u2019s also \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F39488213\\u002F\"}],\"text\":\"early data suggesting\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" that \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F32669715\\u002F\"}],\"text\":\"certain organs\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" \u2014 such as the heart or brain \u2014 may age faster than others, said Tony Wyss-Coray, a professor of neurology and neurological sciences at Stanford University who was an author of the 2019 study.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":9},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Whether they happen in phases or spurts, it\u2019s not yet clear how all of these molecular changes actually contribute to aging and age-related disease. Still, these types of findings could offer more insight into the biology underlying well-known shifts in middle age, such as slowing metabolism, said Allison Aiello, a professor of epidemiology at the Robert N. Butler Columbia Aging Center.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":true,\"bad\":false,\"index\":10},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"In practice, it could mean that people could be more targeted in managing their health, focusing on specific changes and conditions that correlate with their particular age, said Aditi Gurkar, an assistant professor of medicine at the University of Pittsburgh\u2019s Aging Institute.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":true,\"adsMobile\":true,\"adsMobileHoldout\":false,\"bad\":false,\"index\":11},{\"__typename\":\"Heading2Block\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"What\u2019s next?\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"These findings are \u201cquite interesting, but I would say preliminary,\u201d said Dr. Eric Verdin, the president and chief executive at the Buck Institute for Research on Aging. And it brings up a whole series of questions, he said: \u201cWhat\u2019s happening? Which organ or collection of organs is causing these big changes?\u201d\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":12},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"There are other open questions, including if the changes vary from individual to individual or \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2025\\u002F02\\u002F25\\u002Fwell\\u002Flongevity-women-versus-men.html\"}],\"text\":\"between the sexes\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\", and how much lifestyle and behavior may contribute, since there\u2019s increasing evidence that certain events \u2014 like \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.cell.com\\u002Fcell-metabolism\\u002Fabstract\\u002FS1550-4131(24)00079-2\"}],\"text\":\"pregnancy\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\", \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fwww.nature.com\\u002Farticles\\u002Fs41398-024-03004-9\"}],\"text\":\"trauma and adversity\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" or even a \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"title\":\"\",\"uri\":null,\"url\":\"https:\\u002F\\u002Fpubmed.ncbi.nlm.nih.gov\\u002F38919619\\u002F\"}],\"text\":\"Covid infection\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\" \u2014 can also accelerate biological aging.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":true,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":13},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Experts said they\u2019re eager to answer these questions with longitudinal studies that track changes over a person\u2019s lifetime. That method would account for differences in environment or lifestyle among subjects.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":true,\"bad\":false,\"index\":14},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"\u201cIf you really want to identify whether it\u2019s a linear trend, or there\u2019s these spurts that occur over very specific time periods, you\u2019d want to follow the same people to see if they\u2019re biological\u201d changes, Dr. Aiello said.\"}],\"textAlign\":\"LEFT\"},{\"__typename\":\"Dropzone\",\"adsDesktop\":false,\"adsDesktopHoldout\":false,\"adsHybrid\":false,\"adsMobile\":false,\"adsMobileHoldout\":false,\"bad\":false,\"index\":15},{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"So far, researchers are only \u201ctouching the surface\u201d of how molecular changes relate to aging, said Dr. Luigi Ferrucci, the scientific director of the National Institute on Aging. By learning more, he added, they can help people live better longer and head off disease. \u201cInstead of declining at 70, we can try to make it decline at 75, and gain five years of good life.\u201d\"}],\"textAlign\":\"LEFT\"}]},\"storyFormat\":\"Service Explainer\",\"storylines\":[{\"__typename\":\"AssociatedStoryline\",\"ruleName\":\"styln-aging-guide\",\"storyline\":{\"__typename\":\"Storyline\",\"context\":null,\"displayName\":\"Aging Guide\",\"experimentalJsonBlob\":\"{\\\"data\\\":[{\\\"version\\\":1,\\\"type\\\":\\\"experimentalJsonBlob\\\",\\\"data\\\":[{\\\"version\\\":1,\\\"type\\\":\\\"guide\\\",\\\"data\\\":{\\\"title\\\":\\\"A Guide to Aging Well\\\",\\\"leadIn\\\":\\\"Looking to grow old gracefully? We can help.\\\",\\\"sections\\\":[{\\\"section\\\":[{\\\"type\\\":\\\"bulletedList\\\",\\\"value\\\":[\\\"Heart disease is more common in people over 65, but \\u003Ca href=\\\\\\\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2025\\u002F02\\u002F15\\u002Fhealth\\u002Fheart-disease-aging.html\\\\\\\"\\u003Etreatments are better than ever\\u003C\\u002Fa\\u003E. That can complicate decision-making for older patients.\\\",\\\"Trying to \\u003Ca href=\\\\\\\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2024\\u002F12\\u002F03\\u002Fwell\\u002Flive\\u002Fhealth-span-aging.html\\\\\\\"\\u003Estay healthy into old age is a better goal\\u003C\\u002Fa\\u003E\u00a0than attempting to live as long as possible.\\\",\\\"Most older couples will face health crises and the need for caregiving, and if they haven\u2019t married, \\u003Ca href=\\\\\\\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2024\\u002F11\\u002F10\\u002Fhealth\\u002Felderly-unmarried-couples-caregiving.html\\\\\\\"\\u003Etheir roles and responsibilities can be murky\\u003C\\u002Fa\\u003E.\\\",\\\"Some medical treatments become routine despite lacking strong evidence to show that they\u2019re beneficial. Here are \\u003Ca href=\\\\\\\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2024\\u002F09\\u002F14\\u002Fhealth\\u002Fmedical-practices-treatments-patients.html\\\\\\\"\\u003Ethree common practices\\u003C\\u002Fa\\u003E\u00a0that older patients should question.\\\",\\\"Here\u2019s a \\u003Ca href=\\\\\\\"https:\\u002F\\u002Fwww.nytimes.com\\u002Finteractive\\u002F2024\\u002F06\\u002F24\\u002Fwell\\u002Flive\\u002Fmidlife-health-body-changes-guide.html\\\\\\\"\\u003Ecomplete user\u2019s guide to midlife\\u003C\\u002Fa\\u003E, with help on how to navigate its aches and pains, weight gain, perimenopause, low libido, memory loss, chronic diseases and stress.\\\"]}]}]}}]}]}\",\"guide\":{\"__typename\":\"StorylineGuide\",\"displayName\":\"A Guide to Aging Well\",\"leadIn\":\"Looking to grow old gracefully? We can help.\",\"sections\":[{\"__typename\":\"StorylineGuideSection\",\"items\":[{\"__typename\":\"StorylineGuideItem\",\"content\":{\"__typename\":\"ListBlock\",\"content\":[{\"__typename\":\"ListItemBlock\",\"content\":[{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Heart disease is more common in people over 65, but \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"uri\":\"nyt:\\u002F\\u002Farticle\\u002Fbce5ee51-f4e0-5f70-a976-dd01c7ad1a9b\",\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2025\\u002F02\\u002F15\\u002Fhealth\\u002Fheart-disease-aging.html\"}],\"text\":\"treatments are better than ever\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\". That can complicate decision-making for older patients.\"}]}]},{\"__typename\":\"ListItemBlock\",\"content\":[{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Trying to \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"uri\":\"nyt:\\u002F\\u002Farticle\\u002F06f6424f-23e7-58e7-9512-b07fff8088fa\",\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2024\\u002F12\\u002F03\\u002Fwell\\u002Flive\\u002Fhealth-span-aging.html\"}],\"text\":\"stay healthy into old age is a better goal\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"\u00a0than attempting to live as long as possible.\"}]}]},{\"__typename\":\"ListItemBlock\",\"content\":[{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Most older couples will face health crises and the need for caregiving, and if they haven\u2019t married, \"},{\"__typename\":\"TextInline\",\"formats\":[{\"__typename\":\"LinkFormat\",\"uri\":\"nyt:\\u002F\\u002Farticle\\u002F5f1703c6-8d82-5908-bb05-3bf60cd4e296\",\"url\":\"https:\\u002F\\u002Fwww.nytimes.com\\u002F2024\\u002F11\\u002F10\\u002Fhealth\\u002Felderly-unmarried-couples-caregiving.html\"}],\"text\":\"their roles and responsibilities can be murky\"},{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\".\"}]}]},{\"__typename\":\"ListItemBlock\",\"content\":[{\"__typename\":\"ParagraphBlock\",\"content\":[{\"__typename\":\"TextInline\",\"formats\":[],\"text\":\"Some medical treatments become routine despite lacking strong evidence to show that they\u2019re beneficial. 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