Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen - 20 Minuten<\/title><meta name=\"title\" content=\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"\/><meta name=\"description\" content=\"BRP heisst das vielversprechende Molek\u00fcl, das den Appetit hemmt und bei M\u00e4usen zu Gewichtsabnahme gef\u00fchrt hat. Die Stanford University forscht an dem nat\u00fcrlichen Appetitz\u00fcgler.\"\/><meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-video-preview:-1, max-image-preview:large\"\/><link rel=\"canonical\" href=\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"\/><meta property=\"article:published_time\" content=\"2025-03-11T13:54:40.547Z\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/\",\"name\":\"Front\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/digital\",\"name\":\"Digital\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/digital\/ai\",\"name\":\"AI\"}},{\"@type\":\"ListItem\",\"position\":4,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\",\"name\":\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"}}]}<\/script><meta property=\"og:type\" content=\"article\"\/><meta property=\"og:description\" content=\"Ein Team der Stanford University hat ein Molek\u00fcl entdeckt, das den Appetit z\u00fcgelt \u2013 ganz ohne Nebenwirkungen. Die Entdeckung k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren.\"\/><meta property=\"og:url\" content=\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"\/><meta property=\"og:title\" content=\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"\/><meta property=\"og:locale\" content=\"de_DE\"\/><meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/20min\"\/><meta property=\"og:site_name\" content=\"20 Minuten\"\/><meta property=\"og:image\" content=\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C943%2C644&crop=faces&s=7b39f2db5907d35dbff8dbff9c46f322\"\/><meta property=\"og:image:width\" content=\"1200\"\/><meta property=\"og:image:height\" content=\"675\"\/><meta name=\"twitter:card\" content=\"summary_large_image\"\/><meta name=\"twitter:site\" content=\"@20min\"\/><meta name=\"twitter:title\" content=\"Appetitz\u00fcgler ohne Nebenwirkungen: BRP im Test\"\/><meta name=\"twitter:description\" content=\"Das von der Stanford University entdeckte Molek\u00fcl BRP k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren. Erste Tests an M\u00e4usen sind vielversprechend.\"\/><meta property=\"twitter:image:src\" content=\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C943%2C644&crop=faces&s=7b39f2db5907d35dbff8dbff9c46f322\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"NewsArticle\",\"mainEntityOfPage\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"},\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"20 Minuten\",\"url\":\"https:\/\/www.20min.ch\",\"email\":\"redaktion@20minuten.ch\",\"telephone\":\"+41(0)442486820\",\"sameAs\":[\"https:\/\/www.facebook.com\/20min\",\"https:\/\/twitter.com\/20min\",\"https:\/\/www.instagram.com\/20min.ch\",\"https:\/\/de.wikipedia.org\/wiki\/20_Minuten\"],\"ownershipFundingInfo\":\"https:\/\/www.20min.ch\/impressum\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\/\/www.20min.ch\/icons\/20min_de.png\",\"width\":144,\"height\":192}},\"headline\":\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\",\"alternativeHeadline\":\"FORSCHUNG: KI entdeckt Molek\u00fcl, das schlank macht \u2013 ohne Nebenwirkungen\",\"description\":\"BRP heisst das vielversprechende Molek\u00fcl, das den Appetit hemmt und bei M\u00e4usen zu Gewichtsabnahme gef\u00fchrt hat. Die Stanford University forscht an dem nat\u00fcrlichen Appetitz\u00fcgler.\",\"articleBody\":\"Das Molek\u00fcl BRP ( BRINP2-related peptide )\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt. Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen Stanford University \u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert. Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren. Bald erste Tests am Menschen In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind. Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0 Semaglutid \u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken. Ohne Nebenwirkungen \u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 Katrin Svensson , Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen. Warum ist das wichtig? Fettleibigkeit ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.\",\"image\":[],\"datePublished\":\"2025-03-11T14:54:40+01:00\",\"dateModified\":\"2025-03-11T14:54:40+01:00\",\"author\":[{\"@type\":\"Person\",\"name\":\"Christoph Soltmannowski\"}],\"video\":[],\"keywords\":\"\",\"hasPart\":[{\"@type\":\"Collection\",\"image\":[{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C943%2C644&s=e698e61dab55dffc18e6d07b3739accb\",\"caption\":\"Das BRP-Peptid besteht aus zw\u00f6lf Aminos\u00e4uren (Kugeln sind Atome, St\u00e4bchen sind Bindungen), unterdr\u00fcckt den Appetit und reduziert die Gewichtszunahme.\",\"creditText\":\"Katrin Svensson, Stanford University\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/media.20min.ch\/6\/image\/2023\/12\/22\/9d74f936-52c6-480a-b04c-98050c9328be.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C2048%2C990&fp-x=0.5&fp-y=0.5&s=72c9a7f70eb42649f33ac5eb2e00aef8\",\"caption\":\"BRP wurde an M\u00e4usen getestet \u2013 innert vier Stunden hatten sie nur noch halb so viel Hunger.\",\"creditText\":\"Universit\u00e4t Z\u00fcrich\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/11\/e39afc0d-f35c-4795-a230-85252fd0093b.png?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C1115%2C691&s=ef0a0306ef01539dcdbc213e12eddd38\",\"caption\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"creditText\":\"King of Hearts \/ Wikipedia\"}]}],\"articleSection\":\"AI\"}<\/script><meta name=\"next-head-count\" content=\"26\"\/><link rel=\"preconnect\" 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iIeaQS\">|<\/span><a href=\"\/digital\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">Digital<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><a href=\"\/digital\/ai\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">AI<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><\/div><h1 class=\"sc-46060ef-3 sc-46060ef-6 csIspw egCqAn\">Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen<\/h1><\/section><div class=\"ContentPage_contentPage__YqKjN\"><div class=\"ContentPage_insideFullTopPlaceholder__g16GO\"><div id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/digital\/ai\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/digital\/ai\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><\/div><div class=\"ContentPage_outsideRight__P0Uvf\"><\/div><article class=\"Article_article__sV3bX Article_siteAreaNews__Frmfx\"><header class=\"Article_header__ckSlm\"><div class=\"Article_elementPublishdate__qcso_\"><div class=\"sc-d721210-0 glCzFI\"><span>Publiziert<\/span><time dateTime=\"2025-03-11T14:54:40+01:00\" class=\"sc-d721210-1 ldCIcW\">11. M\u00e4rz 2025, 14:54<\/time><\/div><\/div><div class=\"Article_elementTitle__9QPjy\"><h2><span>FORSCHUNG<span class=\"visually-hidden\" aria-hidden=\"true\" role=\"presentation\">: <\/span><\/span>KI entdeckt Molek\u00fcl, das schlank macht \u2013 ohne Nebenwirkungen<\/h2><\/div><div class=\"Article_elementLead__N3pGr\"><p>Ein Team der Stanford University hat ein Molek\u00fcl entdeckt, das den Appetit z\u00fcgelt \u2013 ganz ohne Nebenwirkungen. Die Entdeckung k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren.<\/p><\/div><div class=\"Article_elementAuthors__LsHcz\"><section class=\"sc-a49778d8-1 kNmdAC\"><div class=\"sc-a49778d8-0 cVViTd\"><div class=\"sc-3d7987c8-2 kbwEQu\"><div class=\"sc-b1f21c84-0 erNuh\"><a href=\"\/autoren\/103280604\/christoph-soltmannowski\" class=\"sc-b1f21c84-2 egfiIF\"><img alt=\"Christoph Soltmannowski\" src=\"https:\/\/image.20min.ch\/2025\/02\/13\/ffd9107c-8b58-43b9-b712-4ec7286b66f8.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=400&h=400&rect=0%2C0%2C2667%2C4000&crop=faces&s=6324f58b8b373b3c95c5b05c4efe7790\" class=\"sc-b1f21c84-1 iTOvpR\"\/><\/a><\/div><div class=\"sc-3d7987c8-0 cWecBK\"><dt class=\"sc-3d7987c8-3 dvBbZq\">von<\/dt><div class=\"sc-3d7987c8-5 hogmkW\"><a href=\"\/autoren\/103280604\/christoph-soltmannowski\" class=\"sc-3d7987c8-8 fCLjyQ\"><dd class=\"sc-3d7987c8-4 kvzacp\">Christoph Soltmannowski<\/dd><\/a><\/div><\/div><\/div><\/div><\/section><\/div><\/header><section class=\"Article_body__60Liu\"><div class=\"Article_elementSlideshow__fbaGO\"><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>Darum gehts<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementList\"><ul><li><p>Forscher der Stanford University haben das Molek\u00fcl BRP entdeckt, das beim Abnehmen hilft.<\/p><\/li><li><p>BRP wirkt gezielt im Gehirn und unterdr\u00fcckt den Appetit ohne Nebenwirkungen.<\/p><\/li><li><p>In <a href=\"\/story\/weniger-versuchstiere-noch-ueber-600-000-864287461997\">Tierversuchen<\/a> f\u00fchrte BRP zu einer deutlichen Gewichtsreduktion bei M\u00e4usen und Schweinen.<\/p><\/li><li><p>Die Entdeckung k\u00f6nnte eine neue \u00c4ra in der <a href=\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\">Behandlung von \u00dcbergewicht<\/a> einleiten.<\/p><\/li><\/ul><\/div><\/div><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Das Molek\u00fcl BRP (<a target=\"_blank\" href=\"https:\/\/en.wikipedia.org\/wiki\/BRINP2-related_peptide\" rel=\"noopener noreferrer\">BRINP2-related peptide<\/a>)\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen <a target=\"_blank\" href=\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/03\/ozempic-rival.html?utm_source=newsletter.genai.works&utm_medium=newsletter&utm_campaign=ilya-sutskever-s-30b-ai-gamble-a-new-path-to-superintelligence&_bhlid=84006a46bfbb0c7c976f579dd9cc310b8b5e2e66\" rel=\"noopener noreferrer\">Stanford University<\/a>\u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Bald erste Tests am Menschen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0<a target=\"_blank\" href=\"https:\/\/de.wikipedia.org\/wiki\/Semaglutid\" rel=\"noopener noreferrer\">Semaglutid<\/a>\u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Ohne Nebenwirkungen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>\u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 <a target=\"_blank\" href=\"https:\/\/profiles.stanford.edu\/katrin-svensson\" rel=\"noopener noreferrer\">Katrin Svensson<\/a>, Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Warum ist das wichtig?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p><a target=\"_blank\" href=\"https:\/\/de.wikipedia.org\/wiki\/Adipositas\" rel=\"noopener noreferrer\">Fettleibigkeit<\/a> ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.<\/p><\/div><div class=\"Article_elementPoll__0I_DP\"><div class=\"sc-c7badfe-0 ldhbtc\"><div class=\"sc-c7badfe-1 sc-c7badfe-2 jyrFy drGMUq\"><p>W\u00fcrdest du ein neues, nat\u00fcrliches Mittel zur Gewichtsreduktion ausprobieren, wenn es keine Nebenwirkungen hat?<\/p><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-3 jyrFy gwdeAf\"><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ja, ich bin immer offen f\u00fcr neue Ans\u00e4tze.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Vielleicht, aber ich warte auf mehr Studien.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nein, ich halte nichts von solchen Mitteln.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ich brauche keine Mittel zur Gewichtsreduktion.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-5 jyrFy GTpCD\"><\/div><\/div><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>F\u00fcr die neusten AI News: Jetzt Push abonnieren!<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementTextblockarray\"><p>Wir bereiten t\u00e4glich diejenigen KI-News auf, die im echten Leben und am Arbeits- oder Ausbildungsplatz einen ganz praktischen Nutzen bringen. Daf\u00fcr lassen wir ganz viel Nerdiges und kurzlebige News zum Thema weg. 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of Hearts \/ Wikipedia\",\"caption\":{\"text\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\"}]}]}},\"caption\":{\"text\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\"}]}]},\"type\":\"image\"}]}},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"list\",\"listType\":\"unordered\",\"listItems\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Forscher der 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\u00dcbergewicht\",\"metadataID\":103281793,\"url\":\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\",\"tenantUrls\":{\"6\":\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\" einleiten.\"}]}]}],\"title\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Darum gehts\"}]}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Das Molek\u00fcl BRP (\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/en.wikipedia.org\/wiki\/BRINP2-related_peptide\\\"\\u003eBRINP2-related peptide\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\")\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/03\/ozempic-rival.html?utm_source=newsletter.genai.works\\u0026amp;utm_medium=newsletter\\u0026amp;utm_campaign=ilya-sutskever-s-30b-ai-gamble-a-new-path-to-superintelligence\\u0026amp;_bhlid=84006a46bfbb0c7c976f579dd9cc310b8b5e2e66\\\"\\u003eStanford University\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert.\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Bald erste Tests am Menschen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/de.wikipedia.org\/wiki\/Semaglutid\\\"\\u003eSemaglutid\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Ohne Nebenwirkungen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/profiles.stanford.edu\/katrin-svensson\\\"\\u003eKatrin Svensson\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\", Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Warum ist das wichtig?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/de.wikipedia.org\/wiki\/Adipositas\\\"\\u003eFettleibigkeit\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.\"}]},{\"type\":\"poll\",\"question\":{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"W\u00fcrdest du ein neues, nat\u00fcrliches Mittel zur Gewichtsreduktion ausprobieren, wenn es keine Nebenwirkungen hat?\"}]}},\"answers\":[{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-1\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ja, ich bin immer offen f\u00fcr neue Ans\u00e4tze.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-2\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Vielleicht, aber ich warte auf mehr Studien.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-3\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein, ich halte nichts von solchen Mitteln.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-4\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ich brauche keine Mittel zur Gewichtsreduktion.\"}]}}]},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Wir bereiten t\u00e4glich diejenigen KI-News auf, die im echten Leben und am Arbeits- oder Ausbildungsplatz einen ganz praktischen Nutzen bringen. 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{"result":{"content":"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen - 20 Minuten<\/title><meta name=\"title\" content=\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"\/><meta name=\"description\" content=\"BRP heisst das vielversprechende Molek\u00fcl, das den Appetit hemmt und bei M\u00e4usen zu Gewichtsabnahme gef\u00fchrt hat. Die Stanford University forscht an dem nat\u00fcrlichen Appetitz\u00fcgler.\"\/><meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-video-preview:-1, max-image-preview:large\"\/><link rel=\"canonical\" href=\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"\/><meta property=\"article:published_time\" content=\"2025-03-11T13:54:40.547Z\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/\",\"name\":\"Front\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/digital\",\"name\":\"Digital\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/digital\/ai\",\"name\":\"AI\"}},{\"@type\":\"ListItem\",\"position\":4,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\",\"name\":\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"}}]}<\/script><meta property=\"og:type\" content=\"article\"\/><meta property=\"og:description\" content=\"Ein Team der Stanford University hat ein Molek\u00fcl entdeckt, das den Appetit z\u00fcgelt \u2013 ganz ohne Nebenwirkungen. Die Entdeckung k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren.\"\/><meta property=\"og:url\" content=\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"\/><meta property=\"og:title\" content=\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\"\/><meta property=\"og:locale\" content=\"de_DE\"\/><meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/20min\"\/><meta property=\"og:site_name\" content=\"20 Minuten\"\/><meta property=\"og:image\" content=\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C943%2C644&crop=faces&s=7b39f2db5907d35dbff8dbff9c46f322\"\/><meta property=\"og:image:width\" content=\"1200\"\/><meta property=\"og:image:height\" content=\"675\"\/><meta name=\"twitter:card\" content=\"summary_large_image\"\/><meta name=\"twitter:site\" content=\"@20min\"\/><meta name=\"twitter:title\" content=\"Appetitz\u00fcgler ohne Nebenwirkungen: BRP im Test\"\/><meta name=\"twitter:description\" content=\"Das von der Stanford University entdeckte Molek\u00fcl BRP k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren. Erste Tests an M\u00e4usen sind vielversprechend.\"\/><meta property=\"twitter:image:src\" content=\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C943%2C644&crop=faces&s=7b39f2db5907d35dbff8dbff9c46f322\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"NewsArticle\",\"mainEntityOfPage\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.20min.ch\/story\/forschung-ki-entdeckt-molekuel-das-schlank-macht-ohne-nebenwirkungen-103299331\"},\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"20 Minuten\",\"url\":\"https:\/\/www.20min.ch\",\"email\":\"redaktion@20minuten.ch\",\"telephone\":\"+41(0)442486820\",\"sameAs\":[\"https:\/\/www.facebook.com\/20min\",\"https:\/\/twitter.com\/20min\",\"https:\/\/www.instagram.com\/20min.ch\",\"https:\/\/de.wikipedia.org\/wiki\/20_Minuten\"],\"ownershipFundingInfo\":\"https:\/\/www.20min.ch\/impressum\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\/\/www.20min.ch\/icons\/20min_de.png\",\"width\":144,\"height\":192}},\"headline\":\"Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen\",\"alternativeHeadline\":\"FORSCHUNG: KI entdeckt Molek\u00fcl, das schlank macht \u2013 ohne Nebenwirkungen\",\"description\":\"BRP heisst das vielversprechende Molek\u00fcl, das den Appetit hemmt und bei M\u00e4usen zu Gewichtsabnahme gef\u00fchrt hat. Die Stanford University forscht an dem nat\u00fcrlichen Appetitz\u00fcgler.\",\"articleBody\":\"Das Molek\u00fcl BRP ( BRINP2-related peptide )\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt. Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen Stanford University \u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert. Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren. Bald erste Tests am Menschen In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind. Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0 Semaglutid \u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken. Ohne Nebenwirkungen \u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 Katrin Svensson , Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen. Warum ist das wichtig? Fettleibigkeit ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.\",\"image\":[],\"datePublished\":\"2025-03-11T14:54:40+01:00\",\"dateModified\":\"2025-03-11T14:54:40+01:00\",\"author\":[{\"@type\":\"Person\",\"name\":\"Christoph Soltmannowski\"}],\"video\":[],\"keywords\":\"\",\"hasPart\":[{\"@type\":\"Collection\",\"image\":[{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/11\/a5dbc799-091e-407c-83dd-29f8c8200866.png?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C943%2C644&s=e698e61dab55dffc18e6d07b3739accb\",\"caption\":\"Das BRP-Peptid besteht aus zw\u00f6lf Aminos\u00e4uren (Kugeln sind Atome, St\u00e4bchen sind Bindungen), unterdr\u00fcckt den Appetit und reduziert die Gewichtszunahme.\",\"creditText\":\"Katrin Svensson, Stanford University\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/media.20min.ch\/6\/image\/2023\/12\/22\/9d74f936-52c6-480a-b04c-98050c9328be.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C2048%2C990&fp-x=0.5&fp-y=0.5&s=72c9a7f70eb42649f33ac5eb2e00aef8\",\"caption\":\"BRP wurde an M\u00e4usen getestet \u2013 innert vier Stunden hatten sie nur noch halb so viel Hunger.\",\"creditText\":\"Universit\u00e4t Z\u00fcrich\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/11\/e39afc0d-f35c-4795-a230-85252fd0093b.png?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C1115%2C691&s=ef0a0306ef01539dcdbc213e12eddd38\",\"caption\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"creditText\":\"King of Hearts \/ Wikipedia\"}]}],\"articleSection\":\"AI\"}<\/script><meta name=\"next-head-count\" content=\"26\"\/><link rel=\"preconnect\" 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iIeaQS\">|<\/span><a href=\"\/digital\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">Digital<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><a href=\"\/digital\/ai\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">AI<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><\/div><h1 class=\"sc-46060ef-3 sc-46060ef-6 csIspw egCqAn\">Hoffnung im Kampf gegen Fettleibigkeit: BRP soll Gewichtsverlust erm\u00f6glichen<\/h1><\/section><div class=\"ContentPage_contentPage__YqKjN\"><div class=\"ContentPage_insideFullTopPlaceholder__g16GO\"><div id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/digital\/ai\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/digital\/ai\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><\/div><div class=\"ContentPage_outsideRight__P0Uvf\"><\/div><article class=\"Article_article__sV3bX Article_siteAreaNews__Frmfx\"><header class=\"Article_header__ckSlm\"><div class=\"Article_elementPublishdate__qcso_\"><div class=\"sc-d721210-0 glCzFI\"><span>Publiziert<\/span><time dateTime=\"2025-03-11T14:54:40+01:00\" class=\"sc-d721210-1 ldCIcW\">11. M\u00e4rz 2025, 14:54<\/time><\/div><\/div><div class=\"Article_elementTitle__9QPjy\"><h2><span>FORSCHUNG<span class=\"visually-hidden\" aria-hidden=\"true\" role=\"presentation\">: <\/span><\/span>KI entdeckt Molek\u00fcl, das schlank macht \u2013 ohne Nebenwirkungen<\/h2><\/div><div class=\"Article_elementLead__N3pGr\"><p>Ein Team der Stanford University hat ein Molek\u00fcl entdeckt, das den Appetit z\u00fcgelt \u2013 ganz ohne Nebenwirkungen. Die Entdeckung k\u00f6nnte die Behandlung von \u00dcbergewicht revolutionieren.<\/p><\/div><div class=\"Article_elementAuthors__LsHcz\"><section class=\"sc-a49778d8-1 kNmdAC\"><div class=\"sc-a49778d8-0 cVViTd\"><div class=\"sc-3d7987c8-2 kbwEQu\"><div class=\"sc-b1f21c84-0 erNuh\"><a href=\"\/autoren\/103280604\/christoph-soltmannowski\" class=\"sc-b1f21c84-2 egfiIF\"><img alt=\"Christoph Soltmannowski\" src=\"https:\/\/image.20min.ch\/2025\/02\/13\/ffd9107c-8b58-43b9-b712-4ec7286b66f8.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=400&h=400&rect=0%2C0%2C2667%2C4000&crop=faces&s=6324f58b8b373b3c95c5b05c4efe7790\" class=\"sc-b1f21c84-1 iTOvpR\"\/><\/a><\/div><div class=\"sc-3d7987c8-0 cWecBK\"><dt class=\"sc-3d7987c8-3 dvBbZq\">von<\/dt><div class=\"sc-3d7987c8-5 hogmkW\"><a href=\"\/autoren\/103280604\/christoph-soltmannowski\" class=\"sc-3d7987c8-8 fCLjyQ\"><dd class=\"sc-3d7987c8-4 kvzacp\">Christoph Soltmannowski<\/dd><\/a><\/div><\/div><\/div><\/div><\/section><\/div><\/header><section class=\"Article_body__60Liu\"><div class=\"Article_elementSlideshow__fbaGO\"><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>Darum gehts<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementList\"><ul><li><p>Forscher der Stanford University haben das Molek\u00fcl BRP entdeckt, das beim Abnehmen hilft.<\/p><\/li><li><p>BRP wirkt gezielt im Gehirn und unterdr\u00fcckt den Appetit ohne Nebenwirkungen.<\/p><\/li><li><p>In <a href=\"\/story\/weniger-versuchstiere-noch-ueber-600-000-864287461997\">Tierversuchen<\/a> f\u00fchrte BRP zu einer deutlichen Gewichtsreduktion bei M\u00e4usen und Schweinen.<\/p><\/li><li><p>Die Entdeckung k\u00f6nnte eine neue \u00c4ra in der <a href=\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\">Behandlung von \u00dcbergewicht<\/a> einleiten.<\/p><\/li><\/ul><\/div><\/div><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Das Molek\u00fcl BRP (<a target=\"_blank\" href=\"https:\/\/en.wikipedia.org\/wiki\/BRINP2-related_peptide\" rel=\"noopener noreferrer\">BRINP2-related peptide<\/a>)\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen <a target=\"_blank\" href=\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/03\/ozempic-rival.html?utm_source=newsletter.genai.works&utm_medium=newsletter&utm_campaign=ilya-sutskever-s-30b-ai-gamble-a-new-path-to-superintelligence&_bhlid=84006a46bfbb0c7c976f579dd9cc310b8b5e2e66\" rel=\"noopener noreferrer\">Stanford University<\/a>\u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Bald erste Tests am Menschen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0<a target=\"_blank\" href=\"https:\/\/de.wikipedia.org\/wiki\/Semaglutid\" rel=\"noopener noreferrer\">Semaglutid<\/a>\u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Ohne Nebenwirkungen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>\u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 <a target=\"_blank\" href=\"https:\/\/profiles.stanford.edu\/katrin-svensson\" rel=\"noopener noreferrer\">Katrin Svensson<\/a>, Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Warum ist das wichtig?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p><a target=\"_blank\" href=\"https:\/\/de.wikipedia.org\/wiki\/Adipositas\" rel=\"noopener noreferrer\">Fettleibigkeit<\/a> ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.<\/p><\/div><div class=\"Article_elementPoll__0I_DP\"><div class=\"sc-c7badfe-0 ldhbtc\"><div class=\"sc-c7badfe-1 sc-c7badfe-2 jyrFy drGMUq\"><p>W\u00fcrdest du ein neues, nat\u00fcrliches Mittel zur Gewichtsreduktion ausprobieren, wenn es keine Nebenwirkungen hat?<\/p><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-3 jyrFy gwdeAf\"><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ja, ich bin immer offen f\u00fcr neue Ans\u00e4tze.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Vielleicht, aber ich warte auf mehr Studien.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nein, ich halte nichts von solchen Mitteln.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103299331\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ich brauche keine Mittel zur Gewichtsreduktion.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-5 jyrFy GTpCD\"><\/div><\/div><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>F\u00fcr die neusten AI News: Jetzt Push abonnieren!<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementTextblockarray\"><p>Wir bereiten t\u00e4glich diejenigen KI-News auf, die im echten Leben und am Arbeits- oder Ausbildungsplatz einen ganz praktischen Nutzen bringen. Daf\u00fcr lassen wir ganz viel Nerdiges und kurzlebige News zum Thema weg. 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of Hearts \/ Wikipedia\",\"caption\":{\"text\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\"}]}]}},\"caption\":{\"text\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Stanford University in Kalifornien, USA, auch genannt \u00abDie Farm\u00bb: Hier wurde das Molek\u00fcl entdeckt.\"}]}]},\"type\":\"image\"}]}},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"list\",\"listType\":\"unordered\",\"listItems\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Forscher der 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\u00dcbergewicht\",\"metadataID\":103281793,\"url\":\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\",\"tenantUrls\":{\"6\":\"\/story\/arzt-erklaert-wer-nicht-uebergewichtig-ist-soll-die-finger-davon-lassen-103281793\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\" einleiten.\"}]}]}],\"title\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Darum gehts\"}]}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Das Molek\u00fcl BRP (\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/en.wikipedia.org\/wiki\/BRINP2-related_peptide\\\"\\u003eBRINP2-related peptide\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\")\u00a0ist ein nat\u00fcrlich vorkommendes Peptid \u2013 eine organische Verbindung, die den Appetit z\u00fcgelt.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Entdeckt wurde das Molek\u00fcl von einem Forscherteam der kalifornischen \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/med.stanford.edu\/news\/all-news\/2025\/03\/ozempic-rival.html?utm_source=newsletter.genai.works\\u0026amp;utm_medium=newsletter\\u0026amp;utm_campaign=ilya-sutskever-s-30b-ai-gamble-a-new-path-to-superintelligence\\u0026amp;_bhlid=84006a46bfbb0c7c976f579dd9cc310b8b5e2e66\\\"\\u003eStanford University\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00a0mithilfe k\u00fcnstlicher Intelligenz. Ein speziell entwickelter Algorithmus identifizierte BRP als potenziell wirksam. Dazu hatte er Dutzende von Proteinen aus der Klasse der Prohormone analysiert.\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Prohormone sind biologische Molek\u00fcle, die aktiv werden, wenn sie von anderen Proteinen in kleinere St\u00fccke, sogenannte Peptide, gespalten werden. Einige dieser Peptide fungieren dann als Hormone, die unter anderem den Energiestoffwechsel im Gehirn regulieren.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Bald erste Tests am Menschen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"In Tierversuchen mit M\u00e4usen und Schweinen f\u00fchrte es zu einer deutlichen Reduktion der Nahrungsaufnahme und des K\u00f6rpergewichts. Innert vier Stunden minderte sich ihr Appetit um 50 Prozent. Die Ergebnisse der Tierversuche sind so vielversprechend, dass bereits klinische Studien am Menschen geplant sind.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bisher verf\u00fcgbare Appetitz\u00fcgler-Medikamente wie Ozempic, auch\u00a0\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/de.wikipedia.org\/wiki\/Semaglutid\\\"\\u003eSemaglutid\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00a0genannt, rufen oft Nebenwirkungen wie \u00dcbelkeit oder Muskelschwund hervor. BRP hingegen scheint gezielt und schonend zu wirken.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Ohne Nebenwirkungen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"\u00abDie Rezeptoren, auf die Semaglutid wirkt, befinden sich im Gehirn, aber auch im Darm, in der Bauchspeicheldr\u00fcse und in anderen Geweben\u00bb, sagt\u00a0 \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/profiles.stanford.edu\/katrin-svensson\\\"\\u003eKatrin Svensson\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\", Co-Autorin der Studie und Assistenzprofessorin f\u00fcr Pathologie an der Stanford University. Sie erkl\u00e4rt: \u00abDeshalb hat Ozempic weitreichende Auswirkungen. Es verlangsamt die Nahrungsbewegung durch den Verdauungstrakt und senkt den Blutzuckerspiegel. BRP hingegen wirkt spezifisch in der Hypothalamus-Hirnregion, wo es den Appetit und den Stoffwechsel steuert.\u00bb\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"So kann das Molek\u00fcl BRP den Appetit unterdr\u00fccken, ohne andere Organe zu beeinflussen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Warum ist das wichtig?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/de.wikipedia.org\/wiki\/Adipositas\\\"\\u003eFettleibigkeit\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" ist eine globale Epidemie mit schwerwiegenden gesundheitlichen Folgen wie Diabetes und Herz-Kreislauf-Erkrankungen. Medikamente wie Ozempic haben zwar Fortschritte gebracht, sind aber nicht f\u00fcr alle geeignet und l\u00f6sen oft Nebenwirkungen aus. Die Entdeckung von BRP k\u00f6nnte eine neue \u00c4ra in der Behandlung von \u00dcbergewicht einleiten \u2013 da es effektiver und vertr\u00e4glicher ist. Wenn die klinischen Studien erfolgreich verlaufen, k\u00f6nnte BRP Millionen von Menschen helfen, ihr Gewicht langfristig zu kontrollieren.\"}]},{\"type\":\"poll\",\"question\":{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"W\u00fcrdest du ein neues, nat\u00fcrliches Mittel zur Gewichtsreduktion ausprobieren, wenn es keine Nebenwirkungen hat?\"}]}},\"answers\":[{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-1\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ja, ich bin immer offen f\u00fcr neue Ans\u00e4tze.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-2\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Vielleicht, aber ich warte auf mehr Studien.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-3\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein, ich halte nichts von solchen Mitteln.\"}]}},{\"type\":\"pollItem\",\"id\":\"poll-1im2ito57.poll-item-poll-1im2ito57-4\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ich brauche keine Mittel zur Gewichtsreduktion.\"}]}}]},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Wir bereiten t\u00e4glich diejenigen KI-News auf, die im echten Leben und am Arbeits- oder Ausbildungsplatz einen ganz praktischen Nutzen bringen. 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