Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems - 20 Minuten<\/title><meta name=\"title\" content=\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\"\/><meta name=\"description\" content=\"Antibiotikaresistenzen sind ein wachsendes Problem. Forscher aus Israel haben nun eine neue Quelle f\u00fcr Antibiotika entdeckt \u2013 im menschlichen K\u00f6rper.\"\/><meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-video-preview:-1, max-image-preview:large\"\/><link rel=\"canonical\" href=\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"\/><meta property=\"article:published_time\" content=\"2025-03-06T19:20:01.595Z\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/\",\"name\":\"Front\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/wissen\",\"name\":\"Wissen\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\",\"name\":\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\"}}]}<\/script><meta property=\"og:type\" content=\"article\"\/><meta property=\"og:description\" content=\"Israelische Forscher haben im menschlichen Immunsystem nat\u00fcrliche Antibiotika entdeckt. Ein Durchbruch im Kampf gegen resistente Bakterien.\"\/><meta property=\"og:url\" content=\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"\/><meta property=\"og:title\" content=\"Nat\u00fcrliche Antibiotika: Wissenschaftler entdecken neuen Teil des Immunsystems\"\/><meta property=\"og:locale\" content=\"de_DE\"\/><meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/20min\"\/><meta property=\"og:site_name\" content=\"20 Minuten\"\/><meta property=\"og:image\" content=\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C4000%2C3000&crop=faces&s=89f07505715514b68c33d05dcc8c7cb5\"\/><meta property=\"og:image:width\" content=\"1200\"\/><meta property=\"og:image:height\" content=\"675\"\/><meta name=\"twitter:card\" content=\"summary_large_image\"\/><meta name=\"twitter:site\" content=\"@20min\"\/><meta name=\"twitter:title\" content=\"Dein K\u00f6rper als Antibiotika-Fabrik: Neue Entdeckung aus Israel\"\/><meta name=\"twitter:description\" content=\"Forscher fanden heraus, dass Proteasomen in deinem K\u00f6rper Peptide freisetzen, die Bakterien abt\u00f6ten k\u00f6nnen.\"\/><meta property=\"twitter:image:src\" content=\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C4000%2C3000&crop=faces&s=89f07505715514b68c33d05dcc8c7cb5\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"NewsArticle\",\"mainEntityOfPage\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"},\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"20 Minuten\",\"url\":\"https:\/\/www.20min.ch\",\"email\":\"redaktion@20minuten.ch\",\"telephone\":\"+41(0)442486820\",\"sameAs\":[\"https:\/\/www.facebook.com\/20min\",\"https:\/\/twitter.com\/20min\",\"https:\/\/www.instagram.com\/20min.ch\",\"https:\/\/de.wikipedia.org\/wiki\/20_Minuten\"],\"ownershipFundingInfo\":\"https:\/\/www.20min.ch\/impressum\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\/\/www.20min.ch\/icons\/20min_de.png\",\"width\":144,\"height\":192}},\"headline\":\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\",\"alternativeHeadline\":\"Israel: Forscher entdecken Antibiotika-Produzent im Immunsystem\",\"description\":\"Antibiotikaresistenzen sind ein wachsendes Problem. Forscher aus Israel haben nun eine neue Quelle f\u00fcr Antibiotika entdeckt \u2013 im menschlichen K\u00f6rper.\",\"articleBody\":\"Neue Hoffnung im Kampf gegen resistente Keime : Forschende aus Israel haben einen bislang unbekannten Teil des Immunsystems entdeckt, der helfen k\u00f6nnte, antibiotikaresistente Bakterien in den Griff zu bekommen. Der Fund ist \u00e4hnlich \u00fcberraschend wie die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim . Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger? Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den I mmunmechanismus im Zellm\u00fcll , genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden. Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen? Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen k\u00f6nnen Bakterien abt\u00f6ten . \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb , heisst es in einer Mitteilung. Wie werden Proteasome zum Bakterienkiller? Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann v er\u00e4ndern sie ihre Struktur und Funktion . Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in eine Art \u00abTurbomodus\u00bb . Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC. Wie gross ist das Potenzial? Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein riesiges ungenutztes Reservoir nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen. Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st? Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, e rst noch getestet werden und das werde Zeit in Anspruch nehmen. Hoffen auf massgeschneiderte Peptide Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet neue M\u00f6glichkeiten f\u00fcr die Entwicklung personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten. Die Studie ist im Fachjournal \u00abNature\u00bb erschienen. Darum braucht es Antibiotika-Alternativen Der Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig . Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb. Allein in der Schweiz sterben pro Jahr rund 300 Menschen an Infektionen mit antibiotikaresistenten Erregern. Im Rennen um Alternativen machen auch Forschende der Universit\u00e4t Freiburg mit . Auch k\u00fcnstliche Intelligenz wird zu Rate gezogen .\",\"image\":[],\"datePublished\":\"2025-03-06T20:20:01+01:00\",\"dateModified\":\"2025-03-06T20:20:01+01:00\",\"author\":[{\"@type\":\"Person\",\"name\":\"Fee Anabelle Riebeling\"}],\"video\":[],\"keywords\":\"\",\"hasPart\":[{\"@type\":\"Collection\",\"image\":[{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C3000&s=bb4ab48975a7c60ec2eb177f7eda243d\",\"caption\":\"Manche bakteriellen Infektionen sind kaum mehr in den Griff zu bekommen.\",\"creditText\":\"Getty Images\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/d8aa2fc8-90cb-4ac9-947d-941160d9db42.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C2667&s=664db5f413ed60f40aa164b9b0663229\",\"caption\":\"Der Grund: Viele Keime haben gegen die g\u00e4ngigen Antibiotika Resistenzen gebildet.\",\"creditText\":\"Getty Images\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/3df9c8d8-7d9b-48a8-ad7c-ff57f905434b.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C3000&s=569a3ead505eca002f262395d0403b5b\",\"caption\":\"Entsprechend dringend ist das Finden von Alternativen.\",\"creditText\":\"Getty Images\/Image Source\"}]}],\"articleSection\":\"Wissen\"}<\/script><meta name=\"next-head-count\" content=\"26\"\/><link rel=\"preconnect\" href=\"https:\/\/api.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/api.20min.ch\"\/><link rel=\"preconnect\" href=\"https:\/\/cdn.cookielaw.org\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/cdn.cookielaw.org\"\/><link rel=\"preconnect\" href=\"https:\/\/ats.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/ats.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/beagle.prod.tda.link\"\/><link rel=\"dns-prefetch\" 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class=\"sc-6821256f-0 bXwfqn sc-3584b39c-0 hDUYcV sc-c5c57201-0 eiBLnd sc-c5c57201-1 jipLa-d\"><div id=\"\/23178153471\/de-20minuten.ch\/inside-sticky\/wissen\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/inside-sticky\/wissen\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><\/aside><\/div><\/nav><\/div><div id=\"\/23178153471\/de-20minuten.ch\/outside-welcome\/wissen\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/outside-welcome\/wissen\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><div class=\"layout_layout__yR_n_ layout_contentType__8IYJ_\"><div class=\"layout_content__6MprE\"><section class=\"sc-46060ef-0 WIfmU sc-91f9da13-0 jFqVIG\"><div class=\"sc-46060ef-1 pIKlK\"><a href=\"\/\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">Front<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><a href=\"\/wissen\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">Wissen<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><\/div><h1 class=\"sc-46060ef-3 sc-46060ef-6 csIspw egCqAn\">Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems<\/h1><\/section><div class=\"ContentPage_contentPage__YqKjN\"><div class=\"ContentPage_insideFullTopPlaceholder__g16GO\"><div id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/wissen\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/wissen\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><\/div><div class=\"ContentPage_outsideRight__P0Uvf\"><\/div><article class=\"Article_article__sV3bX Article_siteAreaNews__Frmfx\"><header class=\"Article_header__ckSlm\"><div class=\"Article_elementPublishdate__qcso_\"><div class=\"sc-d721210-0 glCzFI\"><span>Publiziert<\/span><time dateTime=\"2025-03-06T20:20:01+01:00\" class=\"sc-d721210-1 ldCIcW\">6. M\u00e4rz 2025, 20:20<\/time><\/div><\/div><div class=\"Article_elementTitle__9QPjy\"><h2><span>Israel<span class=\"visually-hidden\" aria-hidden=\"true\" role=\"presentation\">: <\/span><\/span>Forscher entdecken Antibiotika-Produzent im Immunsystem<\/h2><\/div><div class=\"Article_elementLead__N3pGr\"><p>Resistente Bakterien sind ein wachsendes Problem. Israelische Forschende haben eine neue Quelle f\u00fcr nat\u00fcrliche Antibiotika entdeckt \u2013 direkt im menschlichen K\u00f6rper.<\/p><\/div><div class=\"Article_elementAuthors__LsHcz\"><section class=\"sc-a49778d8-1 kNmdAC\"><div class=\"sc-a49778d8-0 cVViTd\"><div class=\"sc-3d7987c8-2 kbwEQu\"><div class=\"sc-b1f21c84-0 erNuh\"><a href=\"\/autoren\/27344224\/fee-anabelle-riebeling\" class=\"sc-b1f21c84-2 egfiIF\"><img alt=\"Fee Anabelle Riebeling\" src=\"https:\/\/media.20min.ch\/6\/image\/2024\/12\/03\/4ceeecae-aa70-43ab-9297-e5f3a8ce4495.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=400&h=400&rect=514%2C186%2C3145%2C3082&fp-x=0.508&fp-y=0.291&crop=focalpoint&s=1678eadca1643f819bd291dfb84b50a9\" class=\"sc-b1f21c84-1 iTOvpR\"\/><\/a><\/div><div class=\"sc-3d7987c8-0 cWecBK\"><dt class=\"sc-3d7987c8-3 dvBbZq\">von<\/dt><div class=\"sc-3d7987c8-5 hogmkW\"><a href=\"\/autoren\/27344224\/fee-anabelle-riebeling\" class=\"sc-3d7987c8-8 fCLjyQ\"><dd class=\"sc-3d7987c8-4 kvzacp\">Fee Anabelle Riebeling<\/dd><\/a><\/div><\/div><\/div><\/div><\/section><\/div><\/header><section class=\"Article_body__60Liu\"><div class=\"Article_elementSlideshow__fbaGO\"><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>Darum gehts<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementList\"><ul><li><p>Forschende aus Israel haben einen neuen Immunmechanismus entdeckt, der gegen resistente Bakterien helfen k\u00f6nnte.<\/p><\/li><li><p>Dieser Mechanismus steckt in den Proteasomen, dem M\u00fcllentsorgungssystem der Zellen.<\/p><\/li><li><p>Proteasomen setzen Peptide frei, die Bakterien abt\u00f6ten k\u00f6nnen.<\/p><\/li><li><p>Die Entdeckung k\u00f6nnte eine neue Klasse nat\u00fcrlicher Antibiotika erm\u00f6glichen.<\/p><\/li><li><p>Weltweit sterben j\u00e4hrlich rund 1,3 Millionen Menschen an Infektionen mit resistenten Keimen.<\/p><\/li><\/ul><\/div><\/div><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Neue Hoffnung <strong>im Kampf gegen resistente Keime<\/strong>: Forschende aus Israel haben einen bislang unbekannten Teil des Immunsystems entdeckt, der helfen k\u00f6nnte, antibiotikaresistente Bakterien in den Griff zu bekommen. Der Fund ist \u00e4hnlich \u00fcberraschend wie <a href=\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\">die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim<\/a>.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den <strong>I<\/strong><strong>mmunmechanismus im Zellm\u00fcll<\/strong>, genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen <strong>k\u00f6nnen Bakterien abt\u00f6ten<\/strong>. \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der <a href=\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\">wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb<\/a>, heisst es in einer Mitteilung.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wie werden Proteasome zum Bakterienkiller?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann <strong>v<\/strong><strong>er\u00e4ndern sie ihre Struktur und Funktion<\/strong>. Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in <strong>eine Art \u00abTurbomodus\u00bb<\/strong>.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC.<\/p><\/div><div class=\"Article_elementPoll__0I_DP\"><div class=\"sc-c7badfe-0 ldhbtc\"><div class=\"sc-c7badfe-1 sc-c7badfe-2 jyrFy drGMUq\"><p>Hattest du schon einmal Probleme mit resistenten Bakterien?<\/p><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-3 jyrFy gwdeAf\"><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ja, mehrfach schon.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Bisher einmal.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nicht, dass ich w\u00fcsste.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nein, sicher nicht.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-5 jyrFy GTpCD\"><\/div><\/div><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wie gross ist das Potenzial?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein <strong>riesiges ungenutztes Reservoir<\/strong> nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, <strong>e<\/strong><strong>rst noch getestet<\/strong> werden und das werde Zeit in Anspruch nehmen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Hoffen auf massgeschneiderte Peptide<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet <strong>neue M\u00f6glichkeiten f\u00fcr die Entwicklung<\/strong> personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Die Studie ist im Fachjournal <a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41586-025-08615-w\" rel=\"noopener noreferrer\">\u00abNature\u00bb<\/a> erschienen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Darum braucht es Antibiotika-Alternativen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Der <a href=\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\">Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig<\/a>. Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. <a href=\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\">Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb.<\/a><\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p><a href=\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\">Allein in der Schweiz sterben pro Jahr rund 300 Menschen<\/a> an Infektionen mit antibiotikaresistenten Erregern.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Im Rennen um Alternativen <a href=\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\">machen auch Forschende der Universit\u00e4t Freiburg mit<\/a>. 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Images\/Image Source\",\"caption\":{\"text\":\"Entsprechend dringend ist das Finden von Alternativen.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Entsprechend dringend ist das Finden von Alternativen.\"}]}]}},\"caption\":{\"text\":\"Entsprechend dringend ist das Finden von Alternativen.\",\"elements\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Entsprechend dringend ist das Finden von Alternativen.\"}]}]},\"type\":\"image\"}]}},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"list\",\"listType\":\"unordered\",\"listItems\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Forschende aus Israel haben einen neuen Immunmechanismus entdeckt, der gegen resistente Bakterien helfen k\u00f6nnte.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Dieser Mechanismus steckt in den Proteasomen, dem M\u00fcllentsorgungssystem der Zellen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Proteasomen setzen Peptide frei, die Bakterien abt\u00f6ten k\u00f6nnen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Entdeckung k\u00f6nnte eine neue Klasse nat\u00fcrlicher Antibiotika erm\u00f6glichen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Weltweit sterben j\u00e4hrlich rund 1,3 Millionen Menschen an Infektionen mit resistenten Keimen.\"}]}]}],\"title\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Darum gehts\"}]}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Neue Hoffnung \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eim Kampf gegen resistente Keime\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\": Forschende aus Israel haben einen bislang unbekannten Teil des Immunsystems entdeckt, der helfen k\u00f6nnte, antibiotikaresistente Bakterien in den Griff zu bekommen. Der Fund ist \u00e4hnlich \u00fcberraschend wie \"},{\"type\":\"internalLink\",\"htmlText\":\"die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim\",\"metadataID\":524707013888,\"url\":\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\",\"tenantUrls\":{\"6\":\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eI\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003emmunmechanismus im Zellm\u00fcll\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\", genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ek\u00f6nnen Bakterien abt\u00f6ten\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\". \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der \"},{\"type\":\"internalLink\",\"htmlText\":\"wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb\",\"metadataID\":482822271973,\"url\":\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\",\"tenantUrls\":{\"6\":\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\", heisst es in einer Mitteilung.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Wie werden Proteasome zum Bakterienkiller?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ev\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eer\u00e4ndern sie ihre Struktur und Funktion\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\". Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eeine Art \u00abTurbomodus\u00bb\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC.\"}]},{\"type\":\"poll\",\"question\":{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Hattest du schon einmal Probleme mit resistenten Bakterien?\"}]}},\"answers\":[{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdea0g6\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ja, mehrfach schon.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdea0g7\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bisher einmal.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdolhv0\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nicht, dass ich w\u00fcsste.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdoqj90\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein, sicher nicht.\"}]}}]},{\"type\":\"crosshead\",\"htmlText\":\"Wie gross ist das Potenzial?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eriesiges ungenutztes Reservoir\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ee\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003erst noch getestet\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" werden und das werde Zeit in Anspruch nehmen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Hoffen auf massgeschneiderte Peptide\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eneue M\u00f6glichkeiten f\u00fcr die Entwicklung\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten.\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Studie ist im Fachjournal \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/www.nature.com\/articles\/s41586-025-08615-w\\\"\\u003e\u00abNature\u00bb\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" erschienen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Darum braucht es Antibiotika-Alternativen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Der \"},{\"type\":\"internalLink\",\"htmlText\":\"Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig\",\"metadataID\":232554019730,\"url\":\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\",\"tenantUrls\":{\"6\":\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\". Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. \"},{\"type\":\"internalLink\",\"htmlText\":\"Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb.\",\"metadataID\":210443420312,\"url\":\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\",\"tenantUrls\":{\"6\":\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\"}}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"internalLink\",\"htmlText\":\"Allein in der Schweiz sterben pro Jahr rund 300 Menschen\",\"metadataID\":943463406972,\"url\":\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\",\"tenantUrls\":{\"6\":\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\" an Infektionen mit antibiotikaresistenten Erregern.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Im Rennen um Alternativen \"},{\"type\":\"internalLink\",\"htmlText\":\"machen auch Forschende der Universit\u00e4t Freiburg mit\",\"metadataID\":103295331,\"url\":\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\",\"tenantUrls\":{\"6\":\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\". Auch \"},{\"type\":\"internalLink\",\"htmlText\":\"k\u00fcnstliche Intelligenz wird zu Rate gezogen\",\"metadataID\":103286333,\"url\":\"\/story\/medizin-forscher-loesten-todeskeim-raetsel-in-10-jahren-ki-in-nur-2-tagen-103286333\",\"tenantUrls\":{\"6\":\"\/story\/medizin-forscher-loesten-todeskeim-raetsel-in-10-jahren-ki-in-nur-2-tagen-103286333\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Abonniere in der 20-Minuten-App die Benachrichtigungen des Wissen-Kanals. Du wirst \u00fcber bahnbrechende Erkenntnisse und Entdeckungen aus der Forschung, Erkl\u00e4rungen zu aktuellen Ereignissen und kuriose Nachrichten aus der weiten Welt der Wissenschaft informiert. Auch erh\u00e4ltst du Antworten auf Alltagsfragen und Tipps f\u00fcr ein besseres Leben.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"So gehts: Installiere die neueste Version der 20-Minuten-App. Tippe oben rechts aufs Cockpit (drei Striche mit Kreis), dann auf \u00abMitteilungen\u00bb. W\u00e4hle die gew\u00fcnschten Themen aus und klicke dann \u00abWeiter\u00bb. W\u00e4hle nun, falls gew\u00fcnscht, eine Region aus und klicke \u00abWeiter\u00bb. 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{"result":{"content":"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems - 20 Minuten<\/title><meta name=\"title\" content=\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\"\/><meta name=\"description\" content=\"Antibiotikaresistenzen sind ein wachsendes Problem. Forscher aus Israel haben nun eine neue Quelle f\u00fcr Antibiotika entdeckt \u2013 im menschlichen K\u00f6rper.\"\/><meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-video-preview:-1, max-image-preview:large\"\/><link rel=\"canonical\" href=\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"\/><meta property=\"article:published_time\" content=\"2025-03-06T19:20:01.595Z\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/\",\"name\":\"Front\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/wissen\",\"name\":\"Wissen\"}},{\"@type\":\"ListItem\",\"position\":3,\"item\":{\"@id\":\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\",\"name\":\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\"}}]}<\/script><meta property=\"og:type\" content=\"article\"\/><meta property=\"og:description\" content=\"Israelische Forscher haben im menschlichen Immunsystem nat\u00fcrliche Antibiotika entdeckt. Ein Durchbruch im Kampf gegen resistente Bakterien.\"\/><meta property=\"og:url\" content=\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"\/><meta property=\"og:title\" content=\"Nat\u00fcrliche Antibiotika: Wissenschaftler entdecken neuen Teil des Immunsystems\"\/><meta property=\"og:locale\" content=\"de_DE\"\/><meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/20min\"\/><meta property=\"og:site_name\" content=\"20 Minuten\"\/><meta property=\"og:image\" content=\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C4000%2C3000&crop=faces&s=89f07505715514b68c33d05dcc8c7cb5\"\/><meta property=\"og:image:width\" content=\"1200\"\/><meta property=\"og:image:height\" content=\"675\"\/><meta name=\"twitter:card\" content=\"summary_large_image\"\/><meta name=\"twitter:site\" content=\"@20min\"\/><meta name=\"twitter:title\" content=\"Dein K\u00f6rper als Antibiotika-Fabrik: Neue Entdeckung aus Israel\"\/><meta name=\"twitter:description\" content=\"Forscher fanden heraus, dass Proteasomen in deinem K\u00f6rper Peptide freisetzen, die Bakterien abt\u00f6ten k\u00f6nnen.\"\/><meta property=\"twitter:image:src\" content=\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=1200&h=675&rect=0%2C0%2C4000%2C3000&crop=faces&s=89f07505715514b68c33d05dcc8c7cb5\"\/><script type=\"application\/ld+json\">{\"@context\":\"http:\/\/schema.org\",\"@type\":\"NewsArticle\",\"mainEntityOfPage\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.20min.ch\/story\/antibiotika-isrealische-forscher-entdecken-neuen-teil-des-immunsystems-103296044\"},\"publisher\":{\"@type\":\"NewsMediaOrganization\",\"name\":\"20 Minuten\",\"url\":\"https:\/\/www.20min.ch\",\"email\":\"redaktion@20minuten.ch\",\"telephone\":\"+41(0)442486820\",\"sameAs\":[\"https:\/\/www.facebook.com\/20min\",\"https:\/\/twitter.com\/20min\",\"https:\/\/www.instagram.com\/20min.ch\",\"https:\/\/de.wikipedia.org\/wiki\/20_Minuten\"],\"ownershipFundingInfo\":\"https:\/\/www.20min.ch\/impressum\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\/\/www.20min.ch\/icons\/20min_de.png\",\"width\":144,\"height\":192}},\"headline\":\"Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems\",\"alternativeHeadline\":\"Israel: Forscher entdecken Antibiotika-Produzent im Immunsystem\",\"description\":\"Antibiotikaresistenzen sind ein wachsendes Problem. Forscher aus Israel haben nun eine neue Quelle f\u00fcr Antibiotika entdeckt \u2013 im menschlichen K\u00f6rper.\",\"articleBody\":\"Neue Hoffnung im Kampf gegen resistente Keime : Forschende aus Israel haben einen bislang unbekannten Teil des Immunsystems entdeckt, der helfen k\u00f6nnte, antibiotikaresistente Bakterien in den Griff zu bekommen. Der Fund ist \u00e4hnlich \u00fcberraschend wie die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim . Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger? Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den I mmunmechanismus im Zellm\u00fcll , genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden. Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen? Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen k\u00f6nnen Bakterien abt\u00f6ten . \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb , heisst es in einer Mitteilung. Wie werden Proteasome zum Bakterienkiller? Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann v er\u00e4ndern sie ihre Struktur und Funktion . Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in eine Art \u00abTurbomodus\u00bb . Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC. Wie gross ist das Potenzial? Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein riesiges ungenutztes Reservoir nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen. Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st? Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, e rst noch getestet werden und das werde Zeit in Anspruch nehmen. Hoffen auf massgeschneiderte Peptide Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet neue M\u00f6glichkeiten f\u00fcr die Entwicklung personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten. Die Studie ist im Fachjournal \u00abNature\u00bb erschienen. Darum braucht es Antibiotika-Alternativen Der Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig . Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb. Allein in der Schweiz sterben pro Jahr rund 300 Menschen an Infektionen mit antibiotikaresistenten Erregern. Im Rennen um Alternativen machen auch Forschende der Universit\u00e4t Freiburg mit . Auch k\u00fcnstliche Intelligenz wird zu Rate gezogen .\",\"image\":[],\"datePublished\":\"2025-03-06T20:20:01+01:00\",\"dateModified\":\"2025-03-06T20:20:01+01:00\",\"author\":[{\"@type\":\"Person\",\"name\":\"Fee Anabelle Riebeling\"}],\"video\":[],\"keywords\":\"\",\"hasPart\":[{\"@type\":\"Collection\",\"image\":[{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/da6b3a55-d93d-4bfb-983c-d47092ec5807.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C3000&s=bb4ab48975a7c60ec2eb177f7eda243d\",\"caption\":\"Manche bakteriellen Infektionen sind kaum mehr in den Griff zu bekommen.\",\"creditText\":\"Getty Images\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/d8aa2fc8-90cb-4ac9-947d-941160d9db42.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C2667&s=664db5f413ed60f40aa164b9b0663229\",\"caption\":\"Der Grund: Viele Keime haben gegen die g\u00e4ngigen Antibiotika Resistenzen gebildet.\",\"creditText\":\"Getty Images\"},{\"@type\":\"ImageObject\",\"ContentUrl\":\"https:\/\/image.20min.ch\/2025\/03\/06\/3df9c8d8-7d9b-48a8-ad7c-ff57f905434b.jpeg?auto=format%2Ccompress%2Cenhance&fit=max&w=1200&h=1200&rect=0%2C0%2C4000%2C3000&s=569a3ead505eca002f262395d0403b5b\",\"caption\":\"Entsprechend dringend ist das Finden von Alternativen.\",\"creditText\":\"Getty Images\/Image Source\"}]}],\"articleSection\":\"Wissen\"}<\/script><meta name=\"next-head-count\" content=\"26\"\/><link rel=\"preconnect\" href=\"https:\/\/api.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/api.20min.ch\"\/><link rel=\"preconnect\" href=\"https:\/\/cdn.cookielaw.org\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/cdn.cookielaw.org\"\/><link rel=\"preconnect\" href=\"https:\/\/ats.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/ats.20min.ch\"\/><link rel=\"dns-prefetch\" href=\"https:\/\/beagle.prod.tda.link\"\/><link rel=\"dns-prefetch\" 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fgLGdv\">#WIRSINDZUKUNFT<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Z\u00fcrich\" href=\"\/zuerich\"><span class=\"sc-99b3a5c-1 fgLGdv\">Z\u00fcrich<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Bern\" href=\"\/bern\"><span class=\"sc-99b3a5c-1 fgLGdv\">Bern<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Basel\" href=\"\/basel\"><span class=\"sc-99b3a5c-1 fgLGdv\">Basel<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Zentralschweiz\" href=\"\/zentralschweiz\"><span class=\"sc-99b3a5c-1 fgLGdv\">Zentralschweiz<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Ostschweiz\" href=\"\/ostschweiz\"><span class=\"sc-99b3a5c-1 fgLGdv\">Ostschweiz<\/span><\/a><\/li><li 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title=\"Kino & Streaming\" href=\"\/kinostreaming\"><span class=\"sc-99b3a5c-1 fgLGdv\">Kino & Streaming<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Digital\" href=\"\/digital\"><span class=\"sc-99b3a5c-1 fgLGdv\">Digital<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Wissen\" href=\"\/wissen\"><span class=\"sc-99b3a5c-1 fgLGdv\">Wissen<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Kochen mit FOOBY\" href=\"\/kochen\"><span class=\"sc-99b3a5c-1 fgLGdv\">Kochen mit FOOBY<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Wettbewerbe\" href=\"\/wettbewerbe\"><span class=\"sc-99b3a5c-1 fgLGdv\">Wettbewerbe<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Gutscheine\" href=\"https:\/\/gutscheine.20min.ch\"><span class=\"sc-99b3a5c-1 fgLGdv\">Gutscheine<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Politik\" href=\"\/themen\/politik\"><span class=\"sc-99b3a5c-1 fgLGdv\">Politik<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Alle Themen\" href=\"https:\/\/www.20min.ch\/themen\"><span class=\"sc-99b3a5c-1 fgLGdv\">Alle Themen<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"E-Paper\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/epaper.20min.ch\"><span class=\"sc-99b3a5c-1 fgLGdv\">E-Paper<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Live TV\" href=\"\/video\/live-tv\"><span class=\"sc-99b3a5c-1 fgLGdv\">Live TV<\/span><\/a><\/li><li class=\"sc-99b3a5c-2 sc-99b3a5c-3 gwqDVB kuPALN\"><a class=\"sc-99b3a5c-0 eckruc\" title=\"Leitlinien\" href=\"\/publizistische-leitlinien-20-minuten\"><span class=\"sc-99b3a5c-1 fgLGdv\">Leitlinien<\/span><\/a><\/li><\/ul><button class=\"sc-8307d694-3 jJKvHT\">Mehr<svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/button><\/div><\/div><\/div><\/li><div class=\"sc-3be34ed-2 kgUGQj\"><li class=\"sc-3be34ed-1 sc-3be34ed-4 kIFGPh fDCCRU\"><a class=\"sc-d67e13a6-2 iPLHUj\" href=\"\/video\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws sc-d67e13a6-0 dlmMDN\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#video\"><\/use><\/svg><span class=\"sc-d67e13a6-1 btPuLr\">Video<\/span><\/a><a class=\"sc-d67e13a6-2 iPLHUj\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/fantasy.20min.ch\/de\/\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws sc-d67e13a6-0 dlmMDN\"><use 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href=\"\/wissen\" class=\"sc-46060ef-2 sc-46060ef-4 gJkAGz eeHRbX\">Wissen<\/a><span class=\"sc-46060ef-5 iIeaQS\">|<\/span><\/div><h1 class=\"sc-46060ef-3 sc-46060ef-6 csIspw egCqAn\">Antibiotika: Isrealische Forscher entdecken neuen Teil des Immunsystems<\/h1><\/section><div class=\"ContentPage_contentPage__YqKjN\"><div class=\"ContentPage_insideFullTopPlaceholder__g16GO\"><div id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/wissen\" data-ad-unit-id=\"\/23178153471\/de-20minuten.ch\/inside-full-top\/wissen\" style=\"justify-content:center;align-items:center;text-align:center;display:flex;height:100%;background-color:transparent\"><\/div><\/div><div class=\"ContentPage_outsideRight__P0Uvf\"><\/div><article class=\"Article_article__sV3bX Article_siteAreaNews__Frmfx\"><header class=\"Article_header__ckSlm\"><div class=\"Article_elementPublishdate__qcso_\"><div class=\"sc-d721210-0 glCzFI\"><span>Publiziert<\/span><time dateTime=\"2025-03-06T20:20:01+01:00\" class=\"sc-d721210-1 ldCIcW\">6. M\u00e4rz 2025, 20:20<\/time><\/div><\/div><div class=\"Article_elementTitle__9QPjy\"><h2><span>Israel<span class=\"visually-hidden\" aria-hidden=\"true\" role=\"presentation\">: <\/span><\/span>Forscher entdecken Antibiotika-Produzent im Immunsystem<\/h2><\/div><div class=\"Article_elementLead__N3pGr\"><p>Resistente Bakterien sind ein wachsendes Problem. Israelische Forschende haben eine neue Quelle f\u00fcr nat\u00fcrliche Antibiotika entdeckt \u2013 direkt im menschlichen K\u00f6rper.<\/p><\/div><div class=\"Article_elementAuthors__LsHcz\"><section class=\"sc-a49778d8-1 kNmdAC\"><div class=\"sc-a49778d8-0 cVViTd\"><div class=\"sc-3d7987c8-2 kbwEQu\"><div class=\"sc-b1f21c84-0 erNuh\"><a href=\"\/autoren\/27344224\/fee-anabelle-riebeling\" class=\"sc-b1f21c84-2 egfiIF\"><img alt=\"Fee Anabelle Riebeling\" src=\"https:\/\/media.20min.ch\/6\/image\/2024\/12\/03\/4ceeecae-aa70-43ab-9297-e5f3a8ce4495.jpeg?auto=format%2Ccompress%2Cenhance&fit=crop&w=400&h=400&rect=514%2C186%2C3145%2C3082&fp-x=0.508&fp-y=0.291&crop=focalpoint&s=1678eadca1643f819bd291dfb84b50a9\" class=\"sc-b1f21c84-1 iTOvpR\"\/><\/a><\/div><div class=\"sc-3d7987c8-0 cWecBK\"><dt class=\"sc-3d7987c8-3 dvBbZq\">von<\/dt><div class=\"sc-3d7987c8-5 hogmkW\"><a href=\"\/autoren\/27344224\/fee-anabelle-riebeling\" class=\"sc-3d7987c8-8 fCLjyQ\"><dd class=\"sc-3d7987c8-4 kvzacp\">Fee Anabelle Riebeling<\/dd><\/a><\/div><\/div><\/div><\/div><\/section><\/div><\/header><section class=\"Article_body__60Liu\"><div class=\"Article_elementSlideshow__fbaGO\"><\/div><div class=\"Article_element__Tq_1s\"><div type=\"typeInfoboxSummary\" class=\"sc-92253cc8-0 kGbdVO undefined Default\" data-testid=\"InfoBox\"><div class=\"sc-92253cc8-1 sc-92253cc8-2 bGBSLI duFusH\"><h3>Darum gehts<\/h3><div class=\"sc-92253cc8-3 hknAoe\"><svg width=\"1em\" height=\"1em\" class=\"sc-b8528708-0 fFsCws\"><use href=\"\/_next\/static\/media\/sprite.d5961885.svg#boomerang\"><\/use><\/svg><\/div><\/div><div class=\"sc-92253cc8-1 sc-92253cc8-4 bGBSLI lcCaqX elementList\"><ul><li><p>Forschende aus Israel haben einen neuen Immunmechanismus entdeckt, der gegen resistente Bakterien helfen k\u00f6nnte.<\/p><\/li><li><p>Dieser Mechanismus steckt in den Proteasomen, dem M\u00fcllentsorgungssystem der Zellen.<\/p><\/li><li><p>Proteasomen setzen Peptide frei, die Bakterien abt\u00f6ten k\u00f6nnen.<\/p><\/li><li><p>Die Entdeckung k\u00f6nnte eine neue Klasse nat\u00fcrlicher Antibiotika erm\u00f6glichen.<\/p><\/li><li><p>Weltweit sterben j\u00e4hrlich rund 1,3 Millionen Menschen an Infektionen mit resistenten Keimen.<\/p><\/li><\/ul><\/div><\/div><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Neue Hoffnung <strong>im Kampf gegen resistente Keime<\/strong>: Forschende aus Israel haben einen bislang unbekannten Teil des Immunsystems entdeckt, der helfen k\u00f6nnte, antibiotikaresistente Bakterien in den Griff zu bekommen. Der Fund ist \u00e4hnlich \u00fcberraschend wie <a href=\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\">die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim<\/a>.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den <strong>I<\/strong><strong>mmunmechanismus im Zellm\u00fcll<\/strong>, genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen <strong>k\u00f6nnen Bakterien abt\u00f6ten<\/strong>. \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der <a href=\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\">wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb<\/a>, heisst es in einer Mitteilung.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wie werden Proteasome zum Bakterienkiller?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann <strong>v<\/strong><strong>er\u00e4ndern sie ihre Struktur und Funktion<\/strong>. Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in <strong>eine Art \u00abTurbomodus\u00bb<\/strong>.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC.<\/p><\/div><div class=\"Article_elementPoll__0I_DP\"><div class=\"sc-c7badfe-0 ldhbtc\"><div class=\"sc-c7badfe-1 sc-c7badfe-2 jyrFy drGMUq\"><p>Hattest du schon einmal Probleme mit resistenten Bakterien?<\/p><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-3 jyrFy gwdeAf\"><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Ja, mehrfach schon.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Bisher einmal.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nicht, dass ich w\u00fcsste.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><label><input name=\"103296044\" type=\"radio\" class=\"sc-c7badfe-4 jQczuo\"\/><span class=\"sc-c7badfe-9 bwIsay\"><span>Nein, sicher nicht.<\/span><span class=\"sc-c7badfe-7 cqemkj\"><\/span><\/span><\/label><\/div><div class=\"sc-c7badfe-1 sc-c7badfe-5 jyrFy GTpCD\"><\/div><\/div><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Wie gross ist das Potenzial?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein <strong>riesiges ungenutztes Reservoir<\/strong> nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st?<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, <strong>e<\/strong><strong>rst noch getestet<\/strong> werden und das werde Zeit in Anspruch nehmen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Hoffen auf massgeschneiderte Peptide<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet <strong>neue M\u00f6glichkeiten f\u00fcr die Entwicklung<\/strong> personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten.<\/p><\/div><div class=\"Article_elementAd__7Cafs\"><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Die Studie ist im Fachjournal <a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41586-025-08615-w\" rel=\"noopener noreferrer\">\u00abNature\u00bb<\/a> erschienen.<\/p><\/div><div class=\"Article_elementCrosshead__b9pyw\"><h2 class=\"crosshead_crosshead__MxhCQ crosshead_siteAreaNews__x10eM crosshead_typeStandard__szEKi\" data-testid=\"Crosshead\">Darum braucht es Antibiotika-Alternativen<\/h2><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Der <a href=\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\">Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig<\/a>. Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. <a href=\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\">Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb.<\/a><\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p><a href=\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\">Allein in der Schweiz sterben pro Jahr rund 300 Menschen<\/a> an Infektionen mit antibiotikaresistenten Erregern.<\/p><\/div><div class=\"Article_elementTextblockarray__WNyan\"><p>Im Rennen um Alternativen <a href=\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\">machen auch Forschende der Universit\u00e4t Freiburg mit<\/a>. 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M\u00fcllentsorgungssystem der Zellen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Proteasomen setzen Peptide frei, die Bakterien abt\u00f6ten k\u00f6nnen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Entdeckung k\u00f6nnte eine neue Klasse nat\u00fcrlicher Antibiotika erm\u00f6glichen.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Weltweit sterben j\u00e4hrlich rund 1,3 Millionen Menschen an Infektionen mit resistenten Keimen.\"}]}]}],\"title\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Darum gehts\"}]}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Neue Hoffnung \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eim Kampf gegen resistente Keime\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\": Forschende aus Israel haben einen bislang unbekannten 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Der Fund ist \u00e4hnlich \u00fcberraschend wie \"},{\"type\":\"internalLink\",\"htmlText\":\"die Entdeckung eines antibiotischen Wirkstoffes im menschlichen Nasenschleim\",\"metadataID\":524707013888,\"url\":\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\",\"tenantUrls\":{\"6\":\"\/story\/epifadin-forscher-finden-antibiotika-stoff-in-menschlicher-nase-524707013888\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Wo sitzt der Erreger abt\u00f6tende Hoffnungstr\u00e4ger?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Das Team um Yifat Merbl vom Weizmann Institute of Science identifizierte den \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eI\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003emmunmechanismus im Zellm\u00fcll\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\", genauer gesagt in den Proteasomen. So nennen Fachleute das M\u00fcllbeseitigungssystem der Zellen. Denn so wie der Mensch seinen Abfall fortschafft, entsorgen auch unsere Zellen st\u00e4ndig Proteine, die besch\u00e4digt sind oder nicht mehr ben\u00f6tigt werden.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Inwiefern k\u00f6nnen Proteasome gegen resistente Keime helfen?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bei der Entsorgung des Proteinm\u00fclls werden Peptide freigesetzt. Einige dieser organischen Verbindungen \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ek\u00f6nnen Bakterien abt\u00f6ten\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\". \u00abDiese Erkenntnisse erweitern unser Verst\u00e4ndnis der angeborenen Abwehrkr\u00e4fte des K\u00f6rpers und bieten neue Hoffnung im Umgang mit der \"},{\"type\":\"internalLink\",\"htmlText\":\"wachsenden Bedrohung durch Antibiotikaresistenzen\u00bb\",\"metadataID\":482822271973,\"url\":\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\",\"tenantUrls\":{\"6\":\"\/story\/neues-antibiotikum-toetet-auch-resistente-keime-482822271973\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\", heisst es in einer Mitteilung.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Wie werden Proteasome zum Bakterienkiller?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Hauptaufgabe der Proteasomen besteht eigentlich darin, alte Proteine zu zerkleinern, damit diese zur Herstellung neuer Proteine recycelt werden k\u00f6nnen. Merbls Team konnte nun aber zeigen, dass die Proteasomen auch erkennen, wenn eine Zelle von Bakterien infiziert wurde. Dann \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ev\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eer\u00e4ndern sie ihre Struktur und Funktion\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\". Sie beginnen, alte Proteine in Waffen umzuwandeln, die die \u00e4ussere Schicht der Bakterien aufreissen und sie t\u00f6ten k\u00f6nnen. Die Reaktion erfolgt schnell. Laut den Forschenden versetzt eine bakterielle Infektion die Proteasomen in \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eeine Art \u00abTurbomodus\u00bb\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Dass das sehr gut funktioniert, zeigten mehrere Experimente des Teams. \u00abDies geschieht \u00fcberall in unserem K\u00f6rper, in allen Zellen, und f\u00fchrt zur Entstehung einer v\u00f6llig neuen Klasse potenzieller nat\u00fcrlicher Antibiotika\u00bb, so Merbl zur BBC.\"}]},{\"type\":\"poll\",\"question\":{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Hattest du schon einmal Probleme mit resistenten Bakterien?\"}]}},\"answers\":[{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdea0g6\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Ja, mehrfach schon.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdea0g7\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Bisher einmal.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdolhv0\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nicht, dass ich w\u00fcsste.\"}]}},{\"type\":\"pollItem\",\"id\":\"doc-1illdea0g5.doc-1illdoqj90\",\"text\":{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein, sicher nicht.\"}]}}]},{\"type\":\"crosshead\",\"htmlText\":\"Wie gross ist das Potenzial?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Gross. Mithilfe eines Algorithmus zur Analyse aller vom menschlichen K\u00f6rper hergestellten Proteine identifizierten sie in 92 Prozent der menschlichen Proteine Peptide mit potenziellen antibakteriellen Eigenschaften. Ihre Simulationen enth\u00fcllten \u00fcber 270\u2019000 bisher unbekannte Peptide, die von Proteasomen freigesetzt werden k\u00f6nnten und ein \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eriesiges ungenutztes Reservoir\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" nat\u00fcrlicher antimikrobieller Wirkstoffe darstellen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Ist das Problem der Antibiotikaresistenzen damit bald gel\u00f6st?\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Nein. Die Neuentdeckung bietet zun\u00e4chst einmal nur Hoffnung. Laut Daniel Davis, Leiter Biowissenschaften und Immunologe am Imperial College London, nannte die Ergebnisse gegen\u00fcber der BBC \u00ab\u00e4usserst provokativ und sehr interessant\u00bb, da sie das Verst\u00e4ndnis davon ver\u00e4nderten, wie der menschliche K\u00f6rper Infektionen bek\u00e4mpft. Allerdings m\u00fcsse die Idee, daraus eine neue Quelle f\u00fcr Antibiotika zu machen, \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003ee\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003erst noch getestet\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" werden und das werde Zeit in Anspruch nehmen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Hoffen auf massgeschneiderte Peptide\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Sollte aus der Theorie Praxis werden, ist das Potenzial riesig. Die von ihrem Team erstellte Peptid-Datenbank \u00aber\u00f6ffnet \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003cstrong\\u003eneue M\u00f6glichkeiten f\u00fcr die Entwicklung\\u003c\/strong\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" personalisierter Behandlungen gegen Infektionen und andere Erkrankungen\u00bb, so Merbl. So k\u00f6nnten nat\u00fcrliche Peptide massgeschneidert werden, um die Immunabwehr von Patienten mit geschw\u00e4chter Immunit\u00e4t zu st\u00e4rken, etwa bei Organtransplantationsempf\u00e4ngern oder Krebspatienten.\"}]},{\"type\":\"ad\",\"availableFor\":{\"desktop\":true,\"app\":true}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Die Studie ist im Fachjournal \"},{\"type\":\"htmlTextItem\",\"htmlText\":\"\\u003ca target=\\\"_blank\\\" href=\\\"https:\/\/www.nature.com\/articles\/s41586-025-08615-w\\\"\\u003e\u00abNature\u00bb\\u003c\/a\\u003e\"},{\"type\":\"htmlTextItem\",\"htmlText\":\" erschienen.\"}]},{\"type\":\"crosshead\",\"htmlText\":\"Darum braucht es Antibiotika-Alternativen\",\"style\":{}},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Der \"},{\"type\":\"internalLink\",\"htmlText\":\"Bedarf an einer Alternative zu herk\u00f6mmlichen Antibiotika ist riesig\",\"metadataID\":232554019730,\"url\":\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\",\"tenantUrls\":{\"6\":\"\/story\/gegen-den-super-tripper-versagen-gaengige-medis-232554019730\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\". Laut Bundesamt f\u00fcr Gesundheit BAG gehen neue Sch\u00e4tzungen davon aus, \u00abdass weltweit pro Jahr fast 1,3 Millionen Menschen an Infektionen mit resistenten Bakterien sterben\u00bb. \"},{\"type\":\"internalLink\",\"htmlText\":\"Die Rede ist von einer \u00ab\u00fcbersehenen Pandemie\u00bb.\",\"metadataID\":210443420312,\"url\":\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\",\"tenantUrls\":{\"6\":\"\/story\/gegen-antibiotika-resistente-bakterien-toeten-jaehrlich-ueber-eine-million-menschen-210443420312\"}}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"internalLink\",\"htmlText\":\"Allein in der Schweiz sterben pro Jahr rund 300 Menschen\",\"metadataID\":943463406972,\"url\":\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\",\"tenantUrls\":{\"6\":\"\/story\/die-schweiz-hat-das-problem-verschlafen-943463406972\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\" an Infektionen mit antibiotikaresistenten Erregern.\"}]},{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Im Rennen um Alternativen \"},{\"type\":\"internalLink\",\"htmlText\":\"machen auch Forschende der Universit\u00e4t Freiburg mit\",\"metadataID\":103295331,\"url\":\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\",\"tenantUrls\":{\"6\":\"\/story\/antibiotika-kampf-gegen-resistente-bakterien-uni-freiburg-schafft-durchbruch-103295331\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\". Auch \"},{\"type\":\"internalLink\",\"htmlText\":\"k\u00fcnstliche Intelligenz wird zu Rate gezogen\",\"metadataID\":103286333,\"url\":\"\/story\/medizin-forscher-loesten-todeskeim-raetsel-in-10-jahren-ki-in-nur-2-tagen-103286333\",\"tenantUrls\":{\"6\":\"\/story\/medizin-forscher-loesten-todeskeim-raetsel-in-10-jahren-ki-in-nur-2-tagen-103286333\"}},{\"type\":\"htmlTextItem\",\"htmlText\":\".\"}]},{\"type\":\"infobox\",\"collapsed\":false,\"infoboxContent\":[{\"type\":\"textBlockArray\",\"items\":[{\"type\":\"htmlTextItem\",\"htmlText\":\"Abonniere in der 20-Minuten-App die Benachrichtigungen des Wissen-Kanals. Du wirst \u00fcber bahnbrechende Erkenntnisse und Entdeckungen aus der Forschung, Erkl\u00e4rungen zu aktuellen Ereignissen und kuriose Nachrichten aus der weiten Welt der Wissenschaft informiert. 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